Publications

Newman, L.E., Novak, S.W., Rojas, G.R., Tadepelle, N., Schiavon, C.R., Grotjahn, D.A., Towers, C.G., Tremblay, M.E., Donnelly, M.P., Ghosh, S., Medina, M., Rocha, S., Rodriguez-Enriquez, R., Chevez, J.A., Lemersal, I., Manor, U.*, Shadel, G.S.* Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal. Nature Cell Biology. 2024 Feb;26(2):194-206. doi: 10.1038/s41556-023-01343-1. Epub 2024 Feb 8. PubMed PMID: 38332353.

News and Views: McArthur K, Kile BT. mtDNA caught in the act again. Nature Cell Biology. 2024;26(2):177-8. doi: 10.1038/s41556-024-01345-7.

Newman, L.E. and Shadel, G.S. Mitochondrial DNA Release in Innate Immune Signaling. Annual Review of Biochemistry. 2023 Jun 20;92:299-332. Review.

Al Khatib I, Deng J, Lei Y, Torres-Odio S, Rojas GR, Newman LE, Chung BK, Symes A, Zhang H, Huang SN, Pommier Y, Khan A, Shadel GS, West AP, Gibson WT, Shutt TE. Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT. Hum Mol Genet. 2023 Jul 20;32(15):2422-2440.

Wu Z., Oeck S., West A.P., Mangalhara K.C., Sainz A.G., Newman L.E., Zhang X., Wu L., Yan Q., Bosenberg M., Liu Y., Sulkowski P.L., Tripple V., Kaech S.M., Glazer P.M., and Shadel G.S. Mitochondrial DNA stress signalling protects the nuclear genome. Nature Metabolism. 9 Dec. 2019.

Schiavon C.R., Turn R.E., Newman L.E., Kahn R.A. ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2. Mol Biol Cell. 2019 May 1;30(10):1198-1213.

Newman L.E., and Shadel, G.S. Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration. J Cell Biol. 2018. Spotlight article.

Cox C.S., McKay S.E., Holmbeck M.A., Christian B.E., Scortea A.C., Tsay A.J., Newman L.E., and Shadel G.S. Mitohormesis in mice via sustained basal activation of mitochondrial and antioxidant signaling. Cell Metabolism, 2018.

Newman L.E., Schiavon C.R., Turn R.E., and Kahn R.A. The small GTPase ARL2 regulates mitochondrial fusion from the intermembrane space. Cell Logist. 2017 Jun 23;7(3):e1340104. PubMed Central PMCID: PMC5602422. Selected for cover art for the issue.

Newman L.E.*, Schiavon C.R.*, Zhou C., Kahn R.A. The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors. PLoS One. 2017 April 5; 12(4): e0175164. doi:10.1371/journal.pone.0175164. PubMed Central PMCID: PMC5381910.

Francis J.W., Newman L.E., Cunningham L.A., and Kahn R.A. A Trimer Consisting of the Tubulin-specific Chaperone TBCD, Regulatory GTPase ARL2, and β-tubulin is Required for Maintaining the Microtubule Network. J Biol Chem. 2017 Mar 10;292(10):4336-4349. PubMed Central PMCID: PMC5354482.

Wigington C.P., Morris K.J., Newman L.E., and Corbett A.H. The Polyadenosine RNA Binding Protein, Zinc Finger Cys3His Protein #14 (ZC3H14), Regulates the Post-transcriptional Processing of a Key ATP Synthase Subunit mRNA. J Biol Chem. 2016 Oct 21;291(43):22442-22459.

Newman L.E.*, Schiavon C.R.*, and Kahn R.A. Plasmids for variable expression of exogenous proteins targeted to the mitochondrial matrix or intermembrane space. Cell Logist. 2016 Oct 13;6(4):e1247939.

Francis J.W., Turn R.E., Newman L.E., Schiavon C., and Kahn R.A. Higher ordering signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of two essential cell functions. Small GTPases. 2016 Oct;7(4):188-196. Review.

Bhatt J.M., Viktorova E.G., Busby T., Wyrozumska P., Newman L.E., Lin H., Lee E., Wright J., Belov G.A., Kahn R.A., Sztul E. A role for a conserved domain within the Sec7 domain Arf guanine nucleotide exchange factor GBF1 in regulating dimerization, localization and function. Am J Physiol Cell Physiol. 2016 Mar 15;310(6):C456-69.

Newman L.E., Zhou C., Mudigonda S., Mattheyses A.L., Paradies E., Marobbio C.M.T., Kahn R.A. The ARL2 GTPase is Required for Mitochondrial Morphology, Motility, and Maintenance of ATP Levels. PLoS One. 2014 Jun 9;9(6):e99270.

*co-authorship